Key result
Asterric acid, isolated from Aspergillus sp., specifically inhibited endothelin-1 binding to the ETA receptor of A10 cells with an IC50 of 1.0 x 10^-5 M.
Population
A10 cells (1 x 10^4 cells/well)
Design
Preclinical
Authors
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Should not yet change practice; hypothesis-generating for non-peptide ETA antagonists in cardiovascular research.
Effect estimate: IC50 1.0 x 10^-5 M
Asterric acid is identified as a novel non-peptide endothelin binding inhibitor specific to the ETA receptor.
Ohashi et al. (1992) studied this question. Asterric acid was evaluated on Inhibition of ET-1 binding to ETA receptor of A10 cells (IC50 1.0 x 10^-5 M). Asterric acid, isolated from Aspergillus sp., specifically inhibited endothelin-1 binding to the ETA receptor of A10 cells with an IC50 of 1.0 x 10^-5 M.
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