Answers are grounded in this paper and cite their sources.
Phosphorothioates were substituted into double-stranded DNA to study protonated Class I A+.C basepairs by 31P NMR. The method was effective in reporting the A+.C pKa. pKa values near 7.0 were found with optimal nearest-neighbor partners. Such pKa values could expand the catalytic repertoire of nucleic acids.
No takes yet. Share an insight, caveat, or question.
Moody et al. (2004) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: