Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

ADVERTISEMENT RETURN TO ISSUEPerspectiveNEXTAntagonists of the P2X7 Receptor. From Lead Identification to Drug DevelopmentSimon D. Guile*†, Lilian Alcaraz†, Timothy N. Birkinshaw†, Keith C. Bowers‡, Mark R. Ebden†, Mark Furber†, and Michael J. Stocks†View Author Information Departments of Medicinal Chemistry and Bioscience, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, U.K.* To whom correspondence should be addressed. Phone: +44-1509-645308. Fax: +44-1509-645512. E-mail: [email protected]†Department of Medicinal Chemistry.‡Department of Bioscience.Cite this: J. Med. Chem. 2009, 52, 10, 3123–3141Publication Date (Web):February 3, 2009Publication History Received4 December 2008Published online3 February 2009Published inissue 28 May 2009https://pubs.acs.org/doi/10.1021/jm801528xhttps://doi.org/10.1021/jm801528xreview-articleACS PublicationsCopyright © 2009 American Chemical SocietyRequest reuse permissionsArticle Views6071Altmetric-Citations115LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Amides,Antagonists,Chemical structure,Receptors,Rodent models Get e-Alerts