Pathologic Effects of Different Doses of Radiostrontium in Mice: Dose Effect Relationship in90Sr-Induced Bone Tumours

In spite of a very extensive literature concerning the carcinogenic effect of radiostrontium there seem to be only a few reports dealing with the various problems related to dose dependency. Studies in this field ( FINKEL et coll. 1957) have mostly been concerned with the relationship between dose and frequency of mice having overt macroscopically detectable osteosarcomas. Many questions still remain which seem to be of interest for a better understanding of the dynamics of tumour formation and its relation to dose and time. In a previous report the main attention was focussed on the Sr-induced carcinomas and their localisation in the mucous membranes of the head, their development and relation to dose (NILSON 1968). A more detailed study concerning the effect of blood and blood-forming tissues and their dependency on dose will be presented in a further paper. The purpose of the present work was to obtain more information concerning the dose-dependent histologic changes in bone and their relation to frequency, location and type of bone tumours. The relation between dose, time of appear