Severe Mycobacterial and Salmonella Infections In Interleukin-12Receptor-Deficient Patients

de Jong R, 2. Altare F, 3. Haagen I-A, 4. et al. (1998) Science. 280:1435–1438. [OpenUrl][1][Abstract/FREE Full Text][2] #### Purpose of the Studies Bacille Calmette-Guerin (BCG) and nontuberculous mycobacteria (NTM) are poorly virulent mycobacteria that sometimes cause disseminated disease in children. It was recently discovered that complete interferon gamma (IFN-γ) receptor deficiency causes a predisposition for this type of infection, and lack of mature granulomas; partial deficiency leads to a milder course of infection with mature granuloma formation. Some patients with disseminated NTM infections, however, do not have this defect. Because interleukin-12 (IL-12) is a potent inducer of IFN-γ, this study evaluated the possibility that IL-12 receptor abnormalities were responsible for disseminated BCG or NTM in the patients without … [1]: {openurl}?query=rft.jtitle%253DScience%26rft.stitle%253DScience%26rft.issn%253D0036-8075%26rft.aulast%253DJong%26rft.auinit1%253DR.%2Bd.%26rft.volume%253D280%26rft.issue%253D5368%26rft.spage%253D1435%26rft.epage%253D1438%26rft.atitle%253DSevere%2BMycobacterial%2Band%2BSalmonella%2BInfections%2Bin%2BInterleukin-12%2BReceptor-Deficient%2BPatients%26rft_id%253Dinfo%253Adoi%252F10.1126%252Fscience.280.5368.1435%26rft_id%253Dinfo%253Apmid%252F9603733%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=sci&resid=280/5368/1435&atom=%2Fpediatrics%2F104%2FSupplement_2%2F397.3.atom