The Anion-Binding Approach to Catalytic Enantioselective Acyl Transfer

This account details the development of a dual-catalysis approach and its application to the kinetic resolution of amines and other enantioselective acyl-transfer reactions. Anion recognition is an essential design element of these processes, which are enabled by the combined action of an achiral 4-( N , N -dimethylamino)pyridine (DMAP) derivative and a chiral anion receptor catalyst. 1 Introduction 2 Kinetic Resolution of Amines 2.1 Benzylic Amines 2.2 Propargylic Amines 2.3 Allylic Amines 2.4 Benzylic Amines Revisited 2.5 Racemic Diamines 3 Desymmetrization of meso -Diamines 4 Miscellaneous Acyl Transfer Reactions 4.1 Steglich Reaction 4.2 Reactions of Isoquinolines with Azlactones 4.3 Acylation of Silyl Ketene Acetals 5 Conclusions