Abbreviations: HBV, Hepatitis B virus; HCV, Hepatitis C virus; Tregs, Regulatory T cells Hepatitis B virus (HBV) and hepatitis C virus (HCV) are hepatotropic viruses that establish chronic persistent infection by effectively escaping the host immune response and can cause immune-mediated liver injury.It has recently become apparent that regulatory T (Treg) cells, specifically CD4 + CD25 + Foxp3 + Treg cells, modulate viral diseases by suppressing antiviral immune responses and regulating inflammatory host injury.The roles of Treg cells in HBV and HCV infections range from suppressing antiviral T cell responses to protecting the liver from immunemediated damage.This review describes Treg cells and subpopulations and focuses on the roles of these cells in HBV and HCV infections.[Immune Network 2016;16(6):330-336]
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