The asymmetric addition of the Sn(II) enolates derived from thioesters to α-iminoesters having the chiral auxiliary on the nitrogen atom proceeds smoothly to afford syn-β-aminoacid derivatives, which are in turn converted to optically active cis-substituted β-lactams.
No takes yet. Share an insight, caveat, or question.
Yamada et al. (1987) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: