Answers are grounded in this paper and cite their sources.
The dose–response relationship of 2-phenoxyethanol, as a general anaesthetic, in adult sockeye salmon (Oncorhynchus nerka) has been investigated. At 11 °C the effective dose (ED50) and lethal dose (LD50) were approximately 43 and 130 ml/100 Imperial gal, respectively. The therapeutic ratio [Formula: see text] was more than 3, indicating a good margin of safety. At a lowered aquarium temperature of 4 °C the anaesthetic effects of 2-phenoxyethanol were potentiated. ED50 and LD50 at this temperature were approximately 25 and 130 ml/100 gal of water, respectively. The therapeutic ratio was more than 5, indicating that the margin of safety was increased by the decrease in temperature.
No takes yet. Share an insight, caveat, or question.
Sehdev et al. (1963) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: