What question did this study set out to answer?

To evaluate the association between the timing of invasive mechanical ventilation initiation and in-hospital clinical outcomes in patients with cardiogenic shock complicating ST-elevation myocardial infarction.

June 1, 2025BMJ OpenOpen Access

Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observational study

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To evaluate the association between the timing of invasive mechanical ventilation initiation and in-hospital clinical outcomes in patients with cardiogenic shock complicating ST-elevation myocardial infarction.
Retrospective multicentre registry study analyzing 672 patients requiring invasive mechanical ventilation out of 1,117 total patients with STEMI and cardiogenic shock across six Middle Eastern countries in the Gulf-Cardiogenic Shock registry.
Patients were stratified into three groups by time from shock diagnosis to ventilation: early (≤15 min; median 15 min, IQR 10–20), intermediate (30 min; median 30 min, IQR 25–35), and late (≥60 min; median 60 min, IQR 45–70).
Mortality risk increased progressively with each minute of delay in ventilation during the first 60 minutes after shock diagnosis, after which the risk plateaued.
Delayed mechanical ventilation was an independent predictor of higher in-hospital mortality (OR 2.14, 95% CI 1.36 to 3.38, p<0.001).

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Implication

Multicentre observational study finds early mechanical ventilation reduces in-hospital mortality in post-STEMI cardiogenic shock, highlighting the importance of timely respiratory support.

Cite This Study

Arabi et al. (2025) studied this question.

synapsesocial.com/papers/6aa0f46eb6e053eb128d38d3 https://doi.org/10.1136/bmjopen-2025-099208

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Implication

Multicentre observational study finds early mechanical ventilation reduces in-hospital mortality in post-STEMI cardiogenic shock, highlighting the importance of timely respiratory support.

Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observational study

Key Points

Discussion

Implication

Cite This Study

Timing of mechanical ventilation and its association with in-hospital outcomes in patients with cardiogenic shock following ST-elevation myocardial infarction: a multicentre observational study

Key Points

Discussion

Implication

Cite This Study

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