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Prostate-specific antigen was first identified by Hara et al. in 19711 and given the name yseminoprotein. In 1978, Sensabaugh and Crim? purified the protein from seminal plasma and characterized it as a potential semen marker with applications in forensic science. In 1979, Wang et al.3 purified the protein from prostate tissue. Since it was found in all types of prostatic tissue but not in any other human tissue it was given the name prostate-specific antigen (PSA).
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Michael J. Duffy (1996) studied this question.
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