Effect of tiamulin on antipyrine kinetics in chickens

Tiamulin {14-deoxy-14[(2-diethylaminoethyl)-mercaptoacetoxy]-mutilin} hydrogen fuma-rate is a semisynthetic antibiotic. It is clinically effective against pathogenic mycoplasma organisms, e.g. Treponema hyodysenteriae, a large number of Gram-positive and some Gram-negative organisms (Drews et al., 1975). Tiamulin has been shown, under controlled laboratory conditions (Laber & Schutze, 1975; Baughn et al., 1978) and against natural infection under field conditions (Stipkovits et al., 1977), to control respiratory tract infections effectively involving Mycoplasma galliseptkum in chickens and turkeys. It has also been demonstrated that tiamulin could be used as an aid in the control of avian coccidiosis produced by Eimeria acervulina and E. tenella in broilers chickens (Cruthers et al., 1980).