The chemical synthesis of the hydroxylated phase‐I‐metabolites 9, 11, and 12 is effected by Triton B catalysed saponification of the bromides 7 and 8 and boron tribromide mediated ether cleavage of 6 and 10 to 11 and 12. The chelated enol 9 was coupled with the bromosugar 13 to afford the glucuronide 14 that was saponified to the phase‐II‐metabolite 15.
No takes yet. Share an insight, caveat, or question.
Krohn et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
More from Archiv der Pharmazie