Key result
The adipose tissue lipophilic index (fifth vs first quintile) was not significantly associated with the risk of ischemic stroke (HR 0.92; 95% CI 0.75-1.13; P=0.1727 for trend).
Why the study?
Does a higher adipose tissue lipophilic index alter the risk of ischemic stroke in adults aged 50-64 years?
Cohort (n=4,946)
Does a higher adipose tissue lipophilic index alter the risk of ischemic stroke in adults aged 50-64 years?
Hazard Ratio: 0.92 (95% CI 0.75–1.13)
p-value: p=0.1727
The adipose tissue lipophilic index, an indicator of membrane fluidity, does not appear to be associated with the risk of ischemic stroke.
No association seen in this cohort; leaves open whether adipose lipophilic index influences ischemic stroke risk.
Diet may influence the risk of ischemic stroke by several mechanisms. A potential and hitherto unknown mechanism may relate to an effect on the lipophilic index, which is a new and convenient indicator of membrane fluidity. This study investigated the association between the adipose tissue lipophilic index and ischemic stroke and its subtypes. A case-cohort study was conducted based on the Danish cohort study Diet, Cancer, and Health, which includes 57,053 subjects aged 50–64 years at enrolment. A subcohort (n = 3500) was randomly drawn from the whole cohort. All ischemic stroke cases were validated and categorized into subtypes. The lipophilic index was calculated based on fatty acid profiles in adipose tissue. Subjects were divided into quintiles and a weighted Cox proportional hazards regression model was used to calculate hazard ratios. After appropriate exclusions, a subcohort of 3194 subjects and 1752 cases of ischemic stroke were included. When comparing the fifth quintile of the lipophilic index with the first quintile, the hazard ratio for ischemic stroke was 0.92 (95% confidence interval 0.75, 1.13) and the trend across quintiles was not statistically significant (p = 0.1727). In conclusion, no association was found between the lipophilic index and ischemic stroke or its subtypes.
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Tram et al. (2018) conducted a cohort in Ischemic stroke (n=4,946). Adipose tissue lipophilic index vs. First quintile of the lipophilic index was evaluated on Ischemic stroke (HR 0.92, 95% CI 0.75-1.13, p=0.1727). The adipose tissue lipophilic index (fifth vs first quintile) was not significantly associated with the risk of ischemic stroke (HR 0.92; 95% CI 0.75-1.13; P=0.1727 for trend).
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