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August 5, 2021European Journal of Preventive CardiologyOpen Access

Cardiometabolic risk assessment by imaging: current status and future perspectives

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Why the study?

Does the presence of hepatic steatosis on CCTA predict cardiovascular events in patients with suspected coronary artery disease?

Design

Editorial

Key result

Hepatic steatosis was an independent predictor of cardiac death, acute coronary syndrome, and late revascularization, enhancing risk discrimination over adverse CCTA findings.

Authors

AAAlexios S. AntonopoulosKTKonstantinos Tsioufis

Discussion

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Member takes

Overview

May refine CCTA risk models in observational data; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does the presence of hepatic steatosis on CCTA predict cardiovascular events in patients with suspected coronary artery disease?

P
Population
1,148 Japanese patients with suspected coronary artery disease undergoing a diagnostic CCTA scan.
E
Exposure
Assessment of hepatic steatosis (HS), defined as a hepatic-to-spleen attenuation ratio of <1.0, via CCTA.
C
Comparator
Absence of hepatic steatosis.
O
Outcome
Composite endpoint of cardiac death, acute coronary syndrome, and late revascularization.composite

Hepatic steatosis assessed during routine CCTA provides incremental prognostic value for cardiovascular events beyond coronary anatomy and traditional risk scores.

Cite This Study

Antonopoulos et al. (2021) conducted an editorial in suspected coronary artery disease (n=1,148). Hepatic steatosis was evaluated on composite endpoint of cardiac death, acute coronary syndrome, and late revascularization. Hepatic steatosis was an independent predictor of cardiac death, acute coronary syndrome, and late revascularization, enhancing risk discrimination over adverse CCTA findings.

synapsesocial.com/papers/6aa101169318be7e6b997caahttps://doi.org/10.1093/eurjpc/zwab139
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