Reaction of nitriles under acidic conditions. Part VI. Synthesis of condensed 4‐chloro‐ and 4‐aminopyrimidines from ortho‐aminonitriles

This is the authors' abstract. We don't add key points for this paper.

Condensation of a nitrile with benzene, furan and thiophene ortho‐aminonitriles in the presence of dry hydrogen chloride yields condensed 4‐chloropyrimidines, condensed 4‐aminopyrimidines or a mixture of the two condensed pyrimidines in varying proportions depending upon the nature of the nitrile and the substrate, ortho‐aminonitrile.