Clear-cell adenocarcinoma (“mesonephroma”) of the vagina.Three cases associated with maternal synthetic nonsteroid estrogen therapy

Three cases of clear-cell adenocarcinom of the vagina occurring in adolescence are reported. During embryonic development of all these patients, their mothers were treated with synthetic nonsteroid estrogen. This hormonal therapy during pregnancy should be considered potentially carcinogenic to the embryo and avoided whenever possible. Two of our 3 patients died 28 months and 13 months after primary surgical treatment and combined ionizing radiation therapy and chemotherapy, respectively. It is important to include malignancy in the differential diagnosis of vaginal bleeding in teenagers.