Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs

Significance Obesity is a major public health issue worldwide. Easy accessibility of junk food is considered a major contributor to the current obesity epidemic. Thus, the impact of maternal overnutrition in determining disease susceptibility in offspring has received wide attention. It has also been shown that the effects of maternal overnutrition are not limited to the immediate offspring but can also be transmitted to successive generations. Among different epigenetic marks, sperm small noncoding RNAs (sncRNAs) have recently been reported as a direct mediator of acquired traits to the progeny following postnatal trauma or paternal diet. Here, we investigate whether sperm sncRNAs contributes to the transmission of metabolic and hedonic phenotypes across generations following maternal overnutrition.