Key result
The presence of fragmented QRS (100% vs 10%, p=0.002) and higher Shanghai Score System points were significantly associated with ventricular fibrillation recurrence in patients with early repolarization syndrome.
Why the study?
Recent studies suggest depolarization abnormalities are involved in some ERS patients, prompting validation of the repolarization-based Shanghai Score System and fQRS for predicting VF recurrence.
Do the Shanghai Score System and the presence of fragmented QRS (fQRS) predict the recurrence of ventricular fibrillation in patients with early repolarization syndrome?
Observational (n=15)
No
Do the Shanghai Score System and the presence of fragmented QRS (fQRS) predict the recurrence of ventricular fibrillation in patients with early repolarization syndrome?
Absolute Event Rate: 100% vs 10%
p-value: p=0.002
The Shanghai Score System and the presence of fragmented QRS on a 12-lead ECG can effectively identify early repolarization syndrome patients at high risk for recurrent ventricular fibrillation.
May support risk stratification in early repolarization syndrome; hypothesis-generating and requires prospective validation.
BACKGROUND: The Shanghai Score System, which weighs electrocardiogram (ECG) findings reflecting repolarization abnormalities, has been proposed for diagnosis of early repolarization syndrome (ERS). However, recent studies have suggested the involvement of depolarization abnormalities in some ERS patients. The aim of this study was to validate the Shanghai Score System in predicting the recurrence of ventricular fibrillation (VF) in ERS patients. The predictive value of fragmented QRS (fQRS) was also investigated. METHODS: Fifteen consecutive ERS patients (14 males, median age of 47 years) with a history of VF were retrospectively reviewed. The Shanghai Score System points were calculated, and the presence of fQRS was evaluated. RESULTS: During the median follow-up period of 79.2 months, five patients experienced VF recurrence. In the VF recurrence group, two patients showed augmented amplitude of J waves with horizontal ST-segment, while the other three patients had dynamic changes in J-wave amplitude. The Shanghai Score System points in the VF recurrence group were higher than those in the VF non-recurrence group (6.5 [range: 5.8-6.8] vs. 4.5 [range: 4.0-4.5], p = 0.002). The presence of fQRS on standard 12-lead ECG was more frequently observed in the VF recurrence group compared with the non-recurrence group (100% vs. 10%, p = 0.002). CONCLUSIONS: The present study demonstrated that the Shanghai Score System could effectively identify ERS patients at high risk for VF recurrence. The results also suggested that the presence of fQRS, a marker of depolarization abnormalities, may be useful for predicting VF recurrence in ERS patients.
No takes yet. Share an insight, caveat, or question.
Yonezu et al. (2021) conducted an observational in Early repolarization syndrome (n=15). Fragmented QRS and Shanghai Score System vs. Absence of fragmented QRS and lower Shanghai Score was evaluated on Presence of fragmented QRS in VF recurrence vs non-recurrence groups (p=0.002). The presence of fragmented QRS (100% vs 10%, p=0.002) and higher Shanghai Score System points were significantly associated with ventricular fibrillation recurrence in patients with early repolarization syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: