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The difference in antioxidation and the mechanism of action of schisandrins and schisantherin in biological and chemical systems was investigated. The antioxidative activities of schisandrin A (SA), schisandrin B (SB) and schisantherin D (SD) isolated from Schisandra chinensis Baill were studied on haemolysis of mouse erythrocytes and on autooxidation of linoleic acid induced by a water-soluble free radical initiator, 2,2′-azobis(2-amidino-propane)dihydrochloride. It was found that SA, SB and SD inhibited haemolysis of erythrocytes but did not inhibit peroxidation of linoleic acid in micelles. Chlorhexidine, an inhibitor of demethylase, significantly inhibited the antioxidative activities of SA, SB and SD on haemolysis. The results indicated that the methoxy groups in SA, SB and SD may be demethylated by demethylase contained in erythrocytes and metabolized to produce phenolic hydroxyl groups which inhibit the peroxidation of erythrocyte membranes.
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Zheng et al. (1997) studied this question.
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