Structural analysis reveals localized molecular constraints differentiating pump and channel currents in microbial rhodopsin, highlighting pathways for novel ion-specific optogenetic tools.
mobility in CsR as a dynamic extracellular barrier to prevent passive conductance. Our findings reveal that molecular constraints that distinguish pump from channel currents are structurally more confined than was generally expected. This knowledge might enable the structure-based design of novel optogenetic tools, which derive from microbial pumps and are therefore ion specific.
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Fudim et al. (2019) studied this question.
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