Key result
GNRI-defined malnutrition risk is strongly linked to higher 2-year mortality in moderate or severe VHD.
Why the study?
Previous studies on nutritional status in valvular heart disease were mostly limited to aortic stenosis, leaving other types of valvular heart diseases underexplored.
Does malnutrition risk assessed by the geriatric nutritional risk index (GNRI) predict mortality and MACEs in patients with moderate or severe valvular heart disease?
Cohort (n=8,908)
Does malnutrition risk assessed by the geriatric nutritional risk index (GNRI) predict mortality and MACEs in patients with moderate or severe valvular heart disease?
Malnutrition risk, assessed by the GNRI, is prevalent across various types of moderate to severe valvular heart disease and provides incremental prognostic information for 2-year mortality and MACEs.
Answers are grounded in this paper and cite their sources.
Supports malnutrition screening in moderate-severe VHD; hypothesis-generating for whether intervention improves survival.
Background: Previous studies on the prevalence and prognosis of nutritional status in valvular heart disease (VHD) were primarily limited to aortic stenosis. The nutritional status of other types of VHDs remained an underexplored area. Objectives: This study aimed to evaluate the prevalence of malnutrition risk in different types of VHD and investigate the association between malnutrition risk and adverse clinical events. Methods: A total of 8,908 patients with moderate or severe VHD in the China-VHD Study underwent echocardiography and malnutrition risk assessment using the geriatric nutritional risk index (GNRI). The primary outcome was 2-year all-cause mortality, while the secondary outcome was 2-year major adverse cardiovascular events (MACEs). Conclusions: Malnutrition risk was prevalent in various VHDs and was strongly associated with increased mortality and MACEs. The GNRI score provided incremental prognostic information for clinical outcomes. Future research is needed to evaluate the impact of nutritional interventions on outcomes in these vulnerable patients.
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Li et al. (2024) conducted a cohort in moderate or severe valvular heart disease (n=8,908). Malnutrition risk (assessed by GNRI) was evaluated on 2-year all-cause mortality (p=< 0.001). Malnutrition risk assessed by the geriatric nutritional risk index was strongly associated with increased 2-year all-cause mortality in patients with moderate or severe VHD (P<0.001).
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