By means of a convergent synthesis strategy, the title substance (Z)‐7‐oxa‐β‐santalol (4) was prepared starting with the side chain synthon 5‐iodo‐2‐methyl‐2‐pentenylmethoxyethoxymethyl ether (7) and the bicyclic synthon ethyl 3‐methylene‐7‐oxabicyclo[2.2.1]hept‐5‐ene‐2‐carboxylate (5). The new santalol analogue 4 is odorless, although the steric requirements for the sandalwood odor are met. The reasons for this are discussed.
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Buchbauer et al. (1995) studied this question.
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