Chronic Hemolytic Anemia With Autoagglutination and Hyperglobulinemia; Report of a Fatal Case

Case Reports1 October 1943CHRONIC HEMOLYTIC ANEMIA WITH AUTOAGGLUTINATION AND HYPERGLOBULINEMIA; REPORT OF A FATAL CASEROY R. KRACKE, M.D., BYRON J. HOFFMAN, M.D.ROY R. KRACKE, M.D.Search for more papers by this author, BYRON J. HOFFMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-19-4-673 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe presence of any intravascular mechanism that destroys red cells in excess of bone marrow compensation results in an anemia of the hemolytic type. Any classification of the hemolytic anemias is difficult because of the large number and wide variety of agents that can destroy red cells. Among such agents are bacterial and parasitic infections, drugs, chemicals, animal poisons, and occasionally red cell destruction occurs as an allergic phenomenon as observed in sensitivity to the beanVicia favaor the pollen of its flower. Chronic familial hemolytic icterus with spherocytosis, increased fragility of the red cells to hypotonic saline solutions...Bibliography1. LANDSTEINER K: Ueber Beziehungen zwischen dem Blutserum und den Körperzellen, München. med. Wchnschr., 1903, xlix, 1812. Newer knowledge of immunology and bacteriology, 1928, University of Chicago Press, Chicago, 898. Google Scholar2. LEVINE : Ukrain. Zentralbl. f. Blutgruppen-forsch., 1928, ii, 1. Google Scholar3. REIMANN RA: Hyperproteinemia as a cause of autoagglutination; observations in a case of myeloma, Jr. Am. Med. Assoc., 1932, xcix, 1411. CrossrefGoogle Scholar4. JACOBSON BM: On a peculiar serum protein, precipitated by Hayem's solution, occurring in multiple myeloma, Proc. Soc. Exper. Biol. and Med., 1935, xxxii, 1257. CrossrefGoogle Scholar5. BONNIGER M: Ein seltener Blutefund (Hyproteinamis bei Myelomkrankheit), Deutsch. med. Wchnschr., 1933, lix, 770-771. Google Scholar6. SWEIGERT CF: Multiple myeloma with hyperproteinemia; case report, Am. Jr. Med. Sci., 1935, cxc, 245. CrossrefGoogle Scholar7. MAGNUS-LEVY A: Multiple myelome. VII. Euglobulinemia. Zur Klink und Pathologie der Amyloidosis, Ztschr. f. klin. Med., 1933, cxxvi, lxii, 62-111. Google Scholar8. ANTOPOLAPPLEBAUMGOLDMAN WIL: Two cases of acute hemolytic anemia with autoagglutination following sulfanilamide therapy, Jr. Am. Med. Assoc., 1939, cxiii, 488. CrossrefGoogle Scholar9. WU H: A new colorimetric method for the determination of plasma proteins, Jr. Biol. Chem., 1922, li, 33. CrossrefGoogle Scholar10. LUTHY F: Klinische Untersuchungen über Serumeiweiskörper bei Lungentuberculose, Schweiz. med. Wchnschr., 1927, lvii, 993. Google Scholar11. LEDENTUVAUCEL GM: La formol gelification dans la trypanosomiase humaine, Bull. Soc. path. exot., 1927, xx, 601. Google Scholar12. CHOPRAMUKHERJEERAO RNSNSS: Studies on protein fractions of blood sera; normal and filarial blood sera, Indian. Jr. Med. Research, 1934, xxii, 171. Google Scholar13. MELENEYWU HEH: Blood serum globulin in schistosomiasis japonica, China Med. Jr., 1924, xxxviii, 357. Google Scholar14. SALVESEN HA: The sarcoid of Boeck, a disease of importance to internal medicine, Acta Med. Scandin., 1935, lxxxvi, 127. Google Scholar15. GUTMANGUTMAN ABEB: Calcium-protein relation in hyperproteinemia: Total and diffusible serum calcium in lymphogranuloma inguinale and myeloma, Proc. Soc. Exper. Biol. and Med., 1936, xxxv, 511. CrossrefGoogle Scholar16. SIAWU RHH: Serum globulin in Kala-azar, China Med. Jr., 1921, xxxv, 527. Google Scholar17. LOEPERFORESTIERTONNET MJJ: L'hyperalbuminose paradoxale du sang des cancereux, Presse méd., 1921, xxix, 333. Google Scholar18. GUTMANGUTMANJILLSONWILLIAMS ABEBRRD: Acid-base equivalance of blood in diseases associated with hyperglobulinemia; with especial reference to lymphogranuloma inguinale and multiple myeloma, Jr. Clin. Invest., 1936, xv, 475. CrossrefGoogle Scholar19. JEGHERSSELESNICK HS: Hyperproteinemia: its significance, Internat. Clin., 1937, iii, 248-279. Google Scholar20. STEWARTHARVEY WEE: Blood transfusion in two cases of autoagglutination, Lancet, 1931, ii, 399. CrossrefGoogle Scholar21. WIENER AS: Blood groups and blood transfusion, 2nd edit., 1939, Chas. C. Thomas, Springfield, Illinois. Google Scholar22. MCCOMBSMCELROY RPJS: Reversible autohemagglutination with peripheral vascular symptoms, Arch. Int. Med., 1937, lix, 107. CrossrefGoogle Scholar23. BOXWELLBIGGER WJW: Autohemagglutination, Jr. Path. and Bact., 1931, xxxiv, 407. CrossrefGoogle Scholar24. BINGPLUM JP: Serum proteins in leucopenia (contribution on question about place (for formation of serum proteins), Acta med. Scandin., 1937, xcii, 415. BING, J.: Further investigations on hyperglobulinemia (is serum-globulin formed from plasma cells and reticulo-endothelial cells?), Acta med. Scandin., 1940, ciii, 565. Google Scholar25. YUILEKNUTTI CLRE: Blood plasma protein as influenced by intravenous injection of gum acacia. The production of chronic hypoproteinemia, Jr. Exper. Med., 1939, lxx, 605. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Emory University Georgia*Received for publication March 2, 1942.From the Department of Pathology, Emory University School of Medicine, Emory University, Georgia. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTHE CLINICAL SIGNIFICANCE OF HYPERGLOBULINEMIA. I. DIAGNOSTIC IMPLICATIONS*ALVAN R. FEINSTEIN, M.D., ROBERT G. PETERSDORF, M.D.Die regeneratorischen h�molytischen An�mien 1 October 1943Volume 19, Issue 4Page: 673-684KeywordsBone marrowCellsDrugsHemolytic anemiaHyperglobulinemiaParasitic diseasesPollenSaline solutions ePublished: 1 December 2008 Issue Published: 1 October 1943 PDF downloadLoading ...