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November 3, 2025Scientific Reports3 citationsOpen Access

Harris Hawks optimization based deep learning models for heart disease diagnosis

ISIsabella ScrepantiBLB LokeshrajaSDS Dharshan

Key Result

The Gated Recurrent Unit (GRU) deep learning model, integrated with Harris Hawks Optimization for feature selection and K-modes clustering, achieved the highest prediction accuracy of 88.03% for cardiovascular disease.

Structured PICO

P
Population
70,000 patient records from a cardiovascular disease dataset, aged 30 to 65 years, were used to train and evaluate deep learning predictive models.
I
Intervention
Deep learning models (including Gated Recurrent Unit, Multilayer Perceptron, and Convolutional Neural Networks) integrated with Harris Hawks Optimization (HHO) for feature selection and K-mode clustering
O
Outcome
Accuracy of cardiovascular disease prediction

Deep learning methodologies integrated with Harris Hawks Optimization for feature selection and K-mode clustering achieved high accuracy (88.03%) in the early detection of cardiovascular disease.

Limitations

  • Future research is needed to address mixture modelling and sophisticated feature engineering methods to further overcome accuracy issues.

Abstract

The medical community demands accurate predictive models for early heart disease diagnosis because heart disease remains a significant worldwide health concern. Deep learning research presents a predictive system for heart disease that uses K-mode clustering to optimize data preparation and implements Harris Hawks Optimization (HHO) for essential feature selection. The Cardiovascular Disease dataset of 70,000 patient records with many clinical parameters was used to develop model training and validation. The accuracy of cardiovascular disease prediction depends on neural networks and other deep learning architectures which analyze patient risk factors to determine disease development. The model operates efficiently using precision, recall, accuracy and the AUC score to evaluate its performance while utilizing the ROC curve. The developed feature selection method applying HHO increases model efficiency while maintaining prediction capabilities by eliminating unneeded features. The Gated Recurrent Unit (GRU) model achieved the highest accuracy of 88.03% among all the tested frameworks. Deep Learning methodologies integrated with advanced feature selection demonstrate high effectiveness in early detection of cardiovascular disease. It leads to efficient diagnostic solutions for health applications that scale across various systems.

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Cite This Study

Screpanti et al. (2025) studied Cardiovascular Disease (n=70,000). Gated Recurrent Unit (GRU) model with Harris Hawks Optimization (HHO) and K-modes clustering vs. Other deep learning architectures (MLP, CNN, LSTM, BiLSTM) was evaluated on Prediction accuracy. The Gated Recurrent Unit (GRU) deep learning model, integrated with Harris Hawks Optimization for feature selection and K-modes clustering, achieved the highest prediction accuracy of 88.03% for cardiovascular disease.

synapsesocial.com/papers/6aa11f07f68c3a7f111a1182https://doi.org/10.1038/s41598-025-22326-2
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