Key result
Higher albumin linked to ~48% lower mortality risk per g/dL in low-risk TAVI patients.
Why the study?
Although TAVI is now indicated for low-risk patients following favorable trial and registry outcomes, temporal trends and long-term outcomes in this population remained to be investigated.
Cohort (n=5,691)
Yes
Clinical trial eligibility, female sex, BMI, and albumin levels may help refine risk stratification for mortality in STS-defined low-risk patients undergoing TAVI.
Answers are grounded in this paper and cite their sources.
May refine mortality risk stratification in low-risk TAVI; hypothesis-generating and requires prospective validation.
BACKGROUND: Transcatheter aortic valve implantation is now indicated in low-risk patients following favorable outcomes in clinical trials and real-world registries. OBJECTIVES: The authors aimed to investigate temporal trends and long-term outcomes in this population. METHODS: Using a multicenter registry database (2010-2025), we stratified 5,691 patients by their Society of Thoracic Surgeons scores: low risk (<4%, n = 1,580 of 5,691 [27.8%]), intermediate risk (4% to 8%, n = 2,388 of 5,691 [42.0%]), and high risk (>8%, n = 1,723 of 5,691 [30.3%]). Low-risk patients were further classified according to clinical trial eligibility. The primary outcomes were crude 30-day and Kaplan-Meier-estimated 4-year all-cause mortalities. RESULTS: ; 95% CI: 0.90-0.98; P = 0.008), and albumin levels (HR: 0.52 per g/dL; 95% CI: 0.36-0.77; P = 0.001) were associated with all-cause mortality in low-risk patients. CONCLUSIONS: Despite the overall expansion of transcatheter aortic valve implantation, procedure volume among low-risk patients has not consistently increased. Clinical trial eligibility, female sex, BMI, and albumin levels may refine risk stratification in Society of Thoracic Surgeons-defined low-risk patients. (Outcomes of transcatheter aortic valve implantation in Japanese patients with aortic stenosis: LAPLACE-TAVI registry; UMIN000031133).
No takes yet. Share an insight, caveat, or question.
Higuchi et al. (2026) conducted a cohort in Aortic stenosis (n=5,691). Transcatheter aortic valve implantation was evaluated on Crude 30-day and Kaplan-Meier-estimated 4-year all-cause mortalities. In low-risk patients undergoing transcatheter aortic valve implantation, albumin levels were significantly associated with all-cause mortality (HR 0.52 per g/dL; 95% CI 0.36-0.77; P=0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: