Key result
cDNA cloning of border disease virus strain Gifhorn yields a severely attenuated virus in cell culture.
The determination of the complete genome sequence of the border disease virus strain Gifhorn enables the production of a severely attenuated virus in cell culture.
Attenuated BDV cDNA clone enables reverse genetics research; leaves open any veterinary applications pending in vivo validation.
The complete genome sequence of the genotype 3 border disease virus strain Gifhorn has been determined; this strain was originally isolated from pigs. This represents the consensus sequence for the virus used to produce the bacterial artificial chromosome (BAC) cDNA clone pBeloGif3, which yields a virus that is severely attenuated in cell culture.
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Fahnøe et al. (2014) studied this question. The complete genome sequence of genotype 3 border disease virus strain Gifhorn was determined and used to produce a cDNA clone yielding a severely attenuated virus in cell culture.
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