Key result
Eight weeks of aerobic or combined cardiac rehabilitation significantly increased serum SIRT1 levels and functional capacity in post-CABG male patients compared to control.
Why the study?
Although cardiac rehabilitation improves functional capacity in post-CABG patients, its effects on serum SIRT1 levels and functional capacity required evaluation.
Does 8 weeks of cardiac rehabilitation training improve serum levels of SIRT1 and functional capacity in post-CABG patients?
RCT (n=45)
randomly divided
No
Does 8 weeks of cardiac rehabilitation training improve serum levels of SIRT1 and functional capacity in post-CABG patients?
Eight weeks of aerobic or combined cardiac rehabilitation training improves functional capacity and increases serum SIRT1 levels in post-CABG patients.
Answers are grounded in this paper and cite their sources.
Supports aerobic or combined exercise in post-CABG cardiac rehab; confirms SIRT1 elevation alongside functional gains.
Background and Objectives: Cardiac rehabilitation improves functional capacity of post-coronary artery bypass grafting (CABG) patients.Therefore, the aim of this study was to evaluate effects of eight weeks of cardiac rehabilitation on serum levels of sirutin1 (SIRT1) and functional capacity of post-CABG patients.Methods: Forty-five non-active men (mean age: 47.4 ± 3.3 years, duration of disease: 150 ± 69.12 months) were randomly divided into three equal groups: aerobic exercise, combined (resistance and aerobic) exercise and control.The subjects performed trainings at 60-75% of maximum heart rate, three sessions a week for eight weeks.Blood samples were collected 24 hours before the first exercise session and 48 hours after the last exercise session.Data were analyzed with SPSS 16.0 using one-way ANOVA and the Tukey post hoc test.P-values less than 0.05 were considered statistically significant.Results: Aerobic and combined exercise increased serum SIRT1 levels and functional capacity.There was no significant decrease in body mass index (P=0.06).The SIRT1 level did not differ significantly between the two exercise groups after the intervention (P=0.91).There were significant difference between the study groups in terms of the travelled distance (P<0.034).Conclusion: Both combined and aerobic exercise can increase serum levels of SIRT1, reduce body mass index and improve functional capacity in CABG patients.
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Alavizadeh et al. (2019) conducted an RCT in Post-coronary artery bypass grafting (CABG) (n=45). Cardiac rehabilitation (aerobic or combined exercise) vs. Control (basic daily living activities) was evaluated on Serum levels of SIRT1 and functional capacity (6-minute walk test) (p=<0.001). Eight weeks of aerobic or combined cardiac rehabilitation significantly increased serum SIRT1 levels and functional capacity in post-CABG male patients compared to control.