The oxybromination of phenols and anilines was achieved in the benign H2O/scCO2 biphasic system using NaBr–H2O2 as the bromine source without the need for metal catalysts or acidic additives. The reactivity of the system is associated with the intrinsic acidity of the medium and the in situ generation of percarbonic acid. High conversions of the starting material were achieved together with very good selectivities under optimized conditions.
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Ganchegui et al. (2006) studied this question.
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