Key result
Elevated cardiac troponin I levels in dialysis patients were strongly associated with increased early (OR 4.81; 95% CI 1.64-14.89) and late (OR 4.31; 95% CI 1.61-10.96) mortality.
Why the study?
Cardiovascular diseases are highly prevalent in ESRD, but the prognostic value of cardiac troponin I in asymptomatic ESRD patients is less conclusive.
Does an abnormal cardiac troponin I level predict in-hospital and 6-month mortality in dialysis patients admitted for non-cardiovascular causes?
Observational (n=460)
Yes
Does an abnormal cardiac troponin I level predict in-hospital and 6-month mortality in dialysis patients admitted for non-cardiovascular causes?
In dialysis patients admitted for non-cardiovascular causes, an elevated admission cTnI level is a strong predictor of both in-hospital and 6-month mortality.
Background: Cardiovascular diseases (CVDs) are highly prevalent among the end-stage renal disease (ESRD) patients. Prognostic value of cardiac troponin I (cTnI) in patients with asymptomatic ESRD is less conclusive. This study was an observational study to evaluate correlation of first admitted cTnI level with early and late (during 6 months) hospitalization and mortality of ESRD patient admitted due to non-acute coronary and non-heart failure causes in ESRD patients. Materials and Methods: In this prospective observational study, 460 dialysis patients without overt CVD who were admitted at two university hospital were included and followed during 6 months. Patients’ demographic information and laboratory investigations including cTnI level and cause of admission were recorded. The association between cTnI level with in-hospital and late mortality was evaluated. Results: cTnI level was higher in female (35.9%), hemodialysis patients (28.1%), and patients with permanent catheter vascular access (29.4%). There were significant differences in level of triglyceride (TG), low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol between patients with normal and abnormal cTnI levels ( P < 0.05). Patients with abnormal cTnI levels had higher level of TG and LDL cholesterol and lower level of HDL cholesterol. cTnI levels were associated with higher in-hospital and 6-month follow-up mortality rate. In logistic regression analysis, only female gender (odds ratio [OR] =1.89, confidence interval [CI] =1.22–3.076) and TG (OR = 1.007, CI = 1.003–1.01) were positively and HDL cholesterol level (OR = 0.994, CI = 0.98–0.99) was negatively associated with increased cTnI level. cTnI level was associated with early (OR = 4.81, CI = 1.64–14.89) and late (OR = 4.31, CI = 1.61–10.96) mortality. Conclusion: Although in this study, cTnI level is not directly associated with cardiovascular disorders and admission and readmission causes, it is a strong predictor of early and late mortality.
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Taheri et al. (2025) conducted an observational in End-stage renal disease on dialysis (n=460). Elevated cardiac troponin I (cTnI) level vs. Normal cTnI level was evaluated on Early mortality (OR 4.81, 95% CI 1.64-14.89). Elevated cardiac troponin I levels in dialysis patients were strongly associated with increased early (OR 4.81; 95% CI 1.64-14.89) and late (OR 4.31; 95% CI 1.61-10.96) mortality.
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