An industrially practicable route to β-halothiophenes such as 2 is based on the title reaction. α-Halothiophenes with additional substituents react analogously. The residence time on and the Al content of the catalyst (Si-rich zeolite) greatly influence the yield and product distribution. β-Halothiophenes are valuable intermediates in the synthesis of drugs and plant protection agents.
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Dettmeier et al. (1987) studied this question.
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