Key result
Gestational diabetes is linked to ~20% higher maternal Lp-PLA2 levels versus healthy pregnancies.
Why the study?
Gestational diabetes mellitus is a common pregnancy complication linked to adverse outcomes, but changes in Lp-PLA2 levels and their relationship with biochemical indexes in GDM required investigation.
Are Lp-PLA2 levels elevated in patients with gestational diabetes mellitus compared to healthy pregnant women?
Cross-Sectional (n=100)
No
Are Lp-PLA2 levels elevated in patients with gestational diabetes mellitus compared to healthy pregnant women?
Lp-PLA2 levels are significantly elevated in gestational diabetes mellitus and positively correlate with insulin resistance and atherogenic lipids, suggesting a potential role in GDM pathophysiology.
Answers are grounded in this paper and cite their sources.
Lp-PLA2 elevation was associated with GDM and insulin resistance markers; hypothesis-generating for prospective biomarker or intervention studies.
Gestational diabetes mellitus (GDM) is one of the most common complications of pregnancy and associated with adverse pregnancy outcomes. The aim of this study was to investigate the changes of lipoprotein-associated phospholipaseA2 (Lp-PLA2) level and its correlation with biochemical indexes in patients with GDM.This observational cross-sectional study was performed among 52 GDM and 48 healthy pregnant women. Automatic biochemical analyzer was employed to test the biochemical indexes, including fasting plasma glucose (FPG), Hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). The lipoprotein-associated phospholipaseA2 (Lp-PLA2) level was evaluated by enzyme-linked immunosorbent assay, and homeostatic model assessment for insulin resistance (HOMA-IR) was calculated.The levels of FPG, HbA1c, HOMA-IR, TG, TC and LDL-C were significantly increased while high-density lipoprotein cholesterol (HDL-C) level was significantly decreased in the GDM group when compared with those in the control group. Lp-PLA2 level in maternal blood in the GDM group was significantly higher than that in the control group (199.125 ± 23.494 vs165.825 ± 15.576 ng/mL, P < .05) and logistic regression analysis further confirmed the association of Lp-PLA2 levels with GDM. Furthermore, Lp-PLA2 positively correlated with HOMA-IR, TC, and LDL-C.Our results confirmed the association of Lp-PLA2 with GDM. This broadens our knowledge on the pathophysiology of GDM and provides insights into the development of new targets for the prevention and treatment of GDM.
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Wang et al. (2021) conducted a cross-sectional in Gestational diabetes mellitus (n=100). Gestational diabetes mellitus vs. Healthy pregnant women was evaluated on Maternal blood Lp-PLA2 level (ng/mL) (p=<0.001). Maternal blood Lp-PLA2 levels were significantly higher in women with gestational diabetes mellitus compared to healthy pregnant women (199.125 vs 165.825 ng/mL, p<0.001).
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