Summary Camptothecin, an inhibitor of cellular nucleic acid synthesis, prevents fowl plague virus replication in BHK 21/13 cells. In the presence of camptothecin the synthesis of haemagglutinin and neuraminidase antigens does not occur; the ribonucleoprotein antigen is synthesized and accumulates only in the cell nucleus; and the synthesis of virus-specific RNA (of which complementary RNA predominates) is reduced considerably.
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Kelly et al. (1974) studied this question.
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