Key result
Coronary Drug Project evaluates multiple lipid-influencing drugs for total mortality in men with prior MI.
Why the study?
Do lipid-influencing drugs reduce total mortality in men with previous myocardial infarction compared to placebo?
Population
8,341 men ages 30 through 64 with coronary heart disease and ECG evidence of previous myocardial infarction.
Comparison
Equine estrogens, clofibrate, dextrothyroxine… vs Lactose placebo.
Design
RCT, Randomly assigned to one of the six treatment groups, Double blind fashion
Follow-up
minimum of five years
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Launches definitive RCT testing of lipid drugs on post-MI mortality; extends prior observational data to randomized long-term evaluation.
RCT (n=8,341)
double blind
randomly assigned
Yes
Do lipid-influencing drugs reduce total mortality in men with previous myocardial infarction compared to placebo?
The Coronary Drug Project was a landmark randomized, double-blind trial designed to evaluate the long-term efficacy of various lipid-lowering agents on mortality in men with prior myocardial infarction.
A 1973 study conducted an RCT in coronary heart disease (n=8,341). Lipid influencing drugs (equine estrogens, clofibrate, dextrothyroxine, nicotinic acid) vs. lactose placebo was evaluated on total mortality. The Coronary Drug Project enrolled 8,341 men with previous myocardial infarction to evaluate the efficacy of several lipid-influencing drugs on total mortality over a minimum of five years.
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