Biotin deficiency is an entity that was once virtually ignored in clinical medicine. It has recently been attracting renewed interest, primarily from pediatricians, because of the progress made in the study of inborn metabolic disorders. This interest is indicated in the articles by Thoene and Mock and their colleagues in this issue of the Journal. A review of the history of biotin research will demonstrate the importance of contributions from different scientific disciplines in elucidating unknown facets of metabolism. It will also reveal a fascinating sequence of events.In 1927 M. A. Boas-Fixsen observed that the feeding of raw . . .
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Kay Tanaka (1981) studied this question.
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