Key result
Fasting blood glucose was an independent predictor of in-hospital adverse cardiac events in patients with STEMI (adjusted OR 1.010).
Why the study?
In STEMI, glucose metabolism disturbances secondary to acute myocardial injury affect acute clinical outcomes, but the role of specific indices as risk factors for in-hospital adverse cardiac events required investigation.
Do glycated haemoglobin, admission random blood glucose, and fasting blood glucose levels predict in-hospital adverse cardiac events in patients with STEMI?
Cohort (n=269)
No
Do glycated haemoglobin, admission random blood glucose, and fasting blood glucose levels predict in-hospital adverse cardiac events in patients with STEMI?
Fasting blood glucose is an independent predictor and the most accurate glucometabolic index for predicting in-hospital adverse cardiac events in patients with STEMI.
Answers are grounded in this paper and cite their sources.
Fasting glucose may aid acute STEMI risk stratification; leaves open whether it outperforms other indices or warrants targeted intervention.
In an ST-segment elevation acute myocardial infarction (STEMI), glucose metabolism undergoes disturbance secondary to acute myocardial injury, which affects the clinical outcome during the acute phase. Glucose metabolic disturbance indices are glycated haemoglobin, admission random glucose, and fasting glucose in blood circulation during STEMI. This is a retrospective cohort study, aimed to investigate whether glycated haemoglobin, admission random blood glucose, and fasting blood glucose levels are the risk factors for developing in-hospital adverse cardiac events in STEMI. The result showed that among the three glucose metabolic disturbance indices, fasting glucose was an independent predictor (adjusted OR: 1.010 (95% CI: 1.001-1.018) and the most accurate factor (AUC 64.9 %) for adverse cardiac events. Other glucose metabolic indices, namely random blood glucose and glycated haemoglobin, were associated with increased odds to develop adverse cardiac events but they did not independently predict adverse cardiac events. Therefore, fasting blood glucose was an independent predictor and the most accurate factor for adverse cardiac events in the acute event of STEMI.
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Hartopo et al. (2022) conducted a cohort in ST-elevation acute myocardial infarction (STEMI) (n=269). Fasting blood glucose was evaluated on In-hospital adverse cardiac events (composite of death, acute heart failure, cardiogenic shock, reinfarction, and ventricular arrhythmia requiring resuscitation) (adjusted OR 1.010, 95% CI 1.001-1.018). Fasting blood glucose was an independent predictor of in-hospital adverse cardiac events in patients with STEMI (adjusted OR 1.010).
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