Thebaine 1 has been converted in four steps, via its cycloadducts 7 with acylnitroso compounds and the derived dimethyl ketals 8 or ethylene ketals 13, into 14β-acylaminocodeinones 5 (R′=Me), analgesics formerly prepared from 14β-aminocodeinone dimethyl ketal 3.
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Gourlay et al. (1997) studied this question.
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