Enzyme-containing hydrogel coatings with abilities to automatically degrade proteins are developed by covalently binding proteases onto poly(ethylene glycol)/methacrylic acid hydrogel surfaces. Such active coatings can be easily applied to hydrophobic polydimethylsiloxane (PDMS) surfaces to impart long-term hydrophilicity and self-cleaning ability, providing an effective and environmentally friendly way to resist protein fouling in the biologically related application of PDMS-based devices.
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Zhang et al. (2015) studied this question.
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