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The effect of gonadectomy was determined on cell-mediated immune response of immature male chickens. Single Comb White Leghorn males were castrated at 3 weeks of age. Response to phytohemagglutinin (PHA) injection as well as graft vs. host (GvH) response were measured at 5, 10, and 15 weeks of age to evaluate cell-mediated immunity. The PHA and GvH responses were inhibited in castrated males. The results suggest that physiological levels of testosterone are needed to stimulate cell-mediated immune response in immature male chickens.
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Magdi M. Mashaly (1984) studied this question.
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