Gallium-67 labeled superparamagnetic iron oxide nanoparticles ([ 67 Ga]-SPION were prepared and evaluated for their altered biodistribution in normal rats. Superparamagnetic iron oxide nanoparticles (SPION) with narrow size distribution were synthesized by a co-precipitation technique using ferrous salts at Fe 3+ /Fe 2+ =2 molar ratio followed by structure identification using XRD, TGA, DSC, VSM, HRSEM, TEM and FT-IR techniques (≈5 nm diameter). In order to trace SPION bio-distribution, the radiolabeled iron oxide nanoparticles were prepared using 67 Ga with a high labeling efficiency (over 96%, RTLC method) and they also showed an excellent stability at room temperature for at least 4 d. The biodistribution of the radiolabeled SPION was checked in normal male rats up to 24 h compared to free Ga 3+ cation biodistribution. The data strongly support the alteration of the tracer accumulation in reticuluendothelial system while the stability of the complex is highly retained.
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Jalilian et al. (2008) studied this question.