Key result
Three-month smoking cessation in COPD restores systemic oxidative balance but fails to improve spirometry.
Why the study?
Does smoking cessation improve oxidant-antioxidant balance in patients with COPD?
Cohort (n=143)
Does smoking cessation improve oxidant-antioxidant balance in patients with COPD?
Smoking cessation for three months improves systemic oxidative stress markers in patients with COPD, although it does not immediately improve spirometric parameters.
Supports encouraging smoking cessation in COPD for oxidative benefits; leaves open lung function effects pending randomized confirmation.
The effect of smoking cessation on the oxidative stress in patients with chronic obstructive pulmonary disease (COPD) was assessed. We recruited 73 smokers with COPD (study group), whose blood was analysed before smoking cessation, after the 1st, 2nd, and 3rd months of abstinence, 35 healthy nonsmokers (Control I), and 35 smokers with COPD (Control II). Blood was taken once in Control I and 4 times (every month) in Control II. In the study group conjugated dienes (CDs) level in plasma and erythrocytes before smoking cessation was 3 and 6.5 times higher than in Control I, respectively (P < 0.001), while thiobarbituric acid-reactive substances (TBARS) level was 89% (P < 0.001) and 51% higher (P < 0.01), respectively. Superoxide dismutase (SOD) activity was 40% higher (P < 0.05) while glutathione peroxidase (GPx) was 41% lower (P < 0.001) than in Control I. In Control II, the similar differences as compared to Control I were observed throughout the study. Smoking cessation resulted in decrease of CDs, TBARS, and SOD and GPx increase, with no changes in catalase and vitamins A and E. COPD is accompanied by oxidative stress. A three-month tobacco abstinence facilitated restoring the oxidant-antioxidant balance systemically, but it did not affect spirometric parameters.
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Woźniak et al. (2013) conducted a cohort in Chronic Obstructive Pulmonary Disease (COPD) (n=143). Smoking cessation vs. Healthy nonsmokers and continuing smokers with COPD was evaluated on Oxidative stress markers (CDs, TBARS, SOD, GPx) and spirometric parameters. Smoking cessation for three months in patients with COPD facilitated restoring the systemic oxidant-antioxidant balance, but did not affect spirometric parameters.
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