Key result
Genomic analysis reveals novel ostrich parvovirus diverges from goose parvovirus through unique deletions and recombination.
Why the study?
An ostrich disease characterized by paralysis and diarrhea has circulated in parts of China, causing substantial economic losses to the ostrich breeding industry.
Identification of a novel recombinant ostrich parvovirus with specific ITR deletions provides insights into cross-species transmission from geese to ostriches.
Distinguishes novel ostrich parvovirus lineage; leaves open its pathogenicity, transmission risk, and surveillance needs.
In recent years, ostrich disease characterized by paralysis and diarrhea has been circulating in some regions of China, causing huge economic losses to the ostrich breeding industry. In our study, clinical samples from diseased ostriches were collected, and only parvovirus was detected. The virus distribution analysis by histopathology and quantitative real-time PCR assays indicated that the virus had a wide range of tissue tropisms. The full-length genome of the ostrich parvovirus (OsPV) was sequenced and comprehensively analyzed. Interestingly, the phylogenetic and alignment results indicated that the OsPV and the goose parvovirus (GPV) form a separate branch. In contrast to GPV strains, OsPV showed 2 new 14 nucleotide deletions in the inverted terminal repeat (ITR) region. Furthermore, recombination analysis indicated that OsPV was a recombination strain between the vaccine strain SYG61v and the virulent strain B strain, with the major parent of OsPV as the SYG61v strain and the minor parent as the B strain. The 14 nucleotide deletions in the ITR region as well as recombination may be some of the reasons for the cross-species transmission of parvovirus from goose to ostrich. The above data will contribute to a better understanding of the molecular biology of the novel OsPV and help to develop the vaccine candidate strain.
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Zhao et al. (2022) studied Ostrich disease characterized by paralysis and diarrhea. Ostrich parvovirus (OsPV) was evaluated on Genomic analysis and tissue tropism. Genomic analysis of a novel ostrich parvovirus revealed it forms a separate branch from goose parvovirus, featuring two new 14-nucleotide deletions in the ITR region and evidence of recombination.
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