Key result
Tumor 1q gain and >50 chromosomes in Ewing sarcoma linked exclusively to mortality.
Why the study?
Are secondary chromosomal aberrations associated with clinical outcome in children and young adults with Ewing sarcoma?
Population
21 children and young adults with Ewing sarcoma
Design
Cohort
Follow-up
latest follow-up (over a 13-year period)
Authors
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May identify higher-risk Ewing sarcoma; leaves open prospective validation before guiding risk stratification.
Observational (n=21)
Are secondary chromosomal aberrations associated with clinical outcome in children and young adults with Ewing sarcoma?
Secondary chromosomal aberrations, such as gain of 1q material and chromosome numbers over 50, may have prognostic significance in Ewing sarcoma.
Kullendorff et al. (1999) conducted an observational in Ewing sarcoma (n=21). Secondary chromosomal aberrations (e.g., gain of 1q material, chromosome numbers >50) vs. Absence of these specific secondary aberrations was evaluated on Mortality (dead at latest follow-up). Gain of 1q material and chromosome numbers over 50 in Ewing sarcoma tumors were recurrent secondary changes restricted to patients who died, suggesting prognostic importance.
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