Key result
Primary aldosteronism treatment linked to improved intrarenal hemodynamics and normalized peak systolic velocity.
Why the study?
Primary aldosteronism causes changes in intrarenal hemodynamics due to both high blood pressure and direct aldosterone levels, prompting an analysis of treatment results via renal artery ultrasound doppler scanning.
Does treatment for primary aldosteronism improve intrarenal hemodynamics measured by ultrasound doppler scanning in patients with primary aldosteronism?
Observational (n=20)
No
Does treatment for primary aldosteronism improve intrarenal hemodynamics measured by ultrasound doppler scanning in patients with primary aldosteronism?
Treatment of primary aldosteronism normalizes intrarenal hemodynamics, with improvements in doppler indices correlating with reductions in aldosterone levels and diastolic blood pressure.
PA treatment normalizes renal Doppler velocities; leaves open whether serial ultrasound improves PA management.
In the structure of arterial hypertension, primary aldosteronism (РА) ranges from 5 to 15%. Changes in intrarenal hemodynamics are due to both high blood pressure and direct aldosterone level. The purpose of the study was to analyze the results of PA treatment according to ultrasound doppler scanning of renal arteries. In general, 55 patients with PA were treated. Renal arteries duplex scanning before and after the treatment was performed in 20 patients. During treatment, the normalization of Vps, Ved, S/D, PI, PI, AT, TAMX indices was recorded in patients. The RI of the interlobar arteries slightly increased, however, it remained within the reference range. The reduction of aldosterone levels led to increase of TAMX index at the level of the renal artery trunk, S/D, RI and decrease in AT at the level of the segmental arteries, as well as increase of Ved and S/D at the level of the interlobar arteries.
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I. V. Zubryk (2019) conducted an observational in Primary aldosteronism (n=20). Treatment for primary aldosteronism (surgical or conservative) vs. Baseline (before treatment) was evaluated on Doppler sonographic indices of renal hemodynamics (e.g., Vps, TAMX, PI, AT) (p=<0.05). Treatment of primary aldosteronism significantly improved intrarenal hemodynamics, including normalization of peak systolic velocity and time-averaged maximum circulation at the renal artery trunk.
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