Brain functional connectivity is altered in patients with Takotsubo Syndrome

Figures

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  Figure 1. (A) Sagittal, (B) coronal and (C) axial views of the network identified using NBS (edge p/t-threshold = 0.001/4.14, network p = 0.041 and edge p/t-threshold = 0.0005/4.5, network p = 0.014) show increased connectivity in patients with TTS compared to controls during rs-fMRI acquisition. Lines (edges) represent functional connections. Brown spheres represent the centroid of each node and are scaled according to the sum of t-statistic values over all of its significant connections. Hotter colors for connections indicate increasing statistical significance. A – anterior, R – right, L – left. (For further details, see Supplemental Table 1). (D) Plot showing functional connectivity (the average z-transformed correlation coefficient for the significant network) in patients with TTS and controls during rs-fMRI. Error bars indicate standard errors.

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  Figure 2. (A) Sagittal, (B) coronal and (C) axial views of the network identified using NBS with a mixed-design ANOVA (edge p/F-threshold = 0.001/17.14, network p = 0.027 and edge p/t-threshold = 0.0005/20.24, network p = 0.049) show increased connectivity in patients with TTS as compared to controls during the cold pressor challenge. Lines (edges) represent functional connections. Brown spheres represent the centroid of each node and are scaled according to the sum of t-statistic values over all of its significant connections. Hotter colors for connections indicate increasing statistical significance. A – anterior, R – right, L – left. (For further details, see Supplemental Table 2). (D) Plots showing functional connectivity (the average z-transformed correlation coefficients for the significant networks) in patients with TTS and controls during the pre-task baseline and cold pressor challenge period, respectively. Error bars indicate standard errors.