What is the optimal dosage of linezolid in treatment of complicated multidrug-resistant tuberculosis?: Table 1—

What is the optimal dosage of linezolid in treatment of complicated multidrug-resistant tuberculosis?To the Editors:In a retrospective study, MIGLIORI et al. [1] have elegantly shown that linezolid 600 mg daily or twice daily added to an individualised multidrug regimen was efficacious in treating multidrug-resistant tuberculosis (MDR-TB).Once-daily dosing was associated with less major adverse effects than twice-daily dosing, corroborating the results of an earlier study in South Korea [2].As a result of the potentially serious side-effects, MIGLIORI et al. [1] have appropriately recommended reserving linezolid treatment for the most complicated cases of MDR-TB.We concur with these views and would like to share our experience regarding the use of linezolid 800 mg once daily in the treatment of extensively drug-resistant tuberculosis (XDR-TB) and fluoroquinolone-resistant MDR-TB.