Key result
Low appendicular skeletal muscle mass index in postmenopausal women was associated with greater resting arterial stiffness and exaggerated hemodynamic responses to muscle metaboreflex activation.
Why the study?
Does low appendicular lean mass in postmenopausal women exaggerate central blood pressure and wave reflection responses to muscle metaboreflex activation compared to normal lean mass?
Observational
Does low appendicular lean mass in postmenopausal women exaggerate central blood pressure and wave reflection responses to muscle metaboreflex activation compared to normal lean mass?
Low appendicular lean mass in postmenopausal women is associated with increased arterial stiffness and exaggerated central blood pressure responses to muscle metaboreflex activation.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for low muscle mass as vascular risk marker in postmenopausal women; prospective studies needed to test causality and utility.
(ASMI), is associated with increased arterial stiffness (brachial-ankle pulse wave velocity, baPWV) and wave reflection (augmentation index, AIx). Blood pressure (BP) responses to metaboreflex activation (post-exercise muscle ischemia, PEMI) are exaggerated in older prehypertensives and hypertensives. We examined peripheral and aortic haemodynamics at rest and during PEMI in postmenopausal women with low-ASMI and normal-ASMI. Resting radial AIx and baPWV as well as brachial and aortic systolic BP, pulse pressure, systolic time index, and subendocardial viability ratio (SEVR) responses to PEMI were greater in women with low-ASMI than normal-ASMI. Increased baPWV associated with low-ASMI may play a major role in the exaggerated pulse pressure and SEVR responses to PEMI in postmenopausal women.
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Figueroa et al. (2016) conducted an observational in Postmenopausal women. Low appendicular skeletal muscle mass index (low-ASMI) vs. Normal-ASMI was evaluated on Peripheral and aortic haemodynamics at rest and during post-exercise muscle ischemia (PEMI). Low appendicular skeletal muscle mass index in postmenopausal women was associated with greater resting arterial stiffness and exaggerated hemodynamic responses to muscle metaboreflex activation.
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