NADH-cytochrome c reductase was not observed in normal rat plasma. NADH-cytochrome c reductase appeared in the plasma of rats after CCl4 administration. The time-course pattern of the enzyme activity was quite different between the sexes the elevation of the activity was markedly enhanced by fasting. NADH-cytochrome c reductase activity detected in the circulating plasma of CCl4-poisoned rats originated from the microsomal NADH-cytochrome b5 reductase system in liver cells. Mechanisms of the leakage of this enzyme into the plasma are discussed.
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Yamamoto et al. (1973) studied this question.
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