Key result
Exogenous NAAG dose-dependently decreases non-quantal acetylcholine release via NMDA receptor activation and nitric oxide synthesis.
Population
Neuromuscular synapse of rat
Design
Preclinical
Authors
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May inform neuromuscular transmission research; leaves open translational relevance in humans.
NAAG modulates non-quantal secretion of acetylcholine at the rat neuromuscular synapse via hydrolysis to glutamate, activation of postsynaptic NMDA receptors, and synthesis of nitric oxide.
Malomouzh et al. (2005) studied this question. N-acetylaspartylglutamate (NAAG) was evaluated on Non-quantal release of acetylcholine (estimated by H-effect amplitude). Application of exogenous NAAG decreased non-quantal release of acetylcholine in a dose-dependent manner via activation of postsynaptic NMDA receptors and synthesis of nitric oxide.
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