Key result
Psychiatric symptoms in active SLE link to decreased regional cerebral glucose metabolism.
Why the study?
Do active SLE patients with psychiatric symptoms have altered regional cerebral metabolic rates for glucose compared to those without psychiatric symptoms?
Cross-Sectional (n=12)
Do active SLE patients with psychiatric symptoms have altered regional cerebral metabolic rates for glucose compared to those without psychiatric symptoms?
PET imaging reveals decreased glucose metabolism in specific brain regions of SLE patients with psychiatric symptoms, which may be related to attentional deficits.
Hypometabolism in prefrontal, parietal, and cingulate regions may underlie attentional deficits in active SLE with psychiatric symptoms; hypothesis-generating for PET biomarkers, needing prospective validation.
To determine brain functional abnormality in systemic lupus erythematosus (SLE) patients with psychiatric symptoms, we evaluated 12 active SLE patients with or without psychiatric symptoms by means of [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (PET), magnetic resonance imaging and neuropsychological testing. Patients with psychiatric symptoms showed significantly poorer performance in tests which subserved attentional function. The PET study revealed that the psychiatric patients had significantly decreased regional cerebral metabolic rates for glucose in the prefrontal, inferior parietal and anterior cingulate regions. Prefrontal, inferior parietal and anterior cingulate dysfunction may be related to attentional deficits that are involved in various psychiatric symptoms in SLE. PET is an invaluable tool to reveal such brain functional abnormality seen in SLE patients with psychiatric symptoms.
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Komatsu et al. (1999) conducted a cross-sectional in Systemic lupus erythematosus (SLE) (n=12). Psychiatric symptoms vs. SLE patients without psychiatric symptoms was evaluated on Regional cerebral metabolic rates for glucose. Active SLE patients with psychiatric symptoms had significantly decreased regional cerebral metabolic rates for glucose in the prefrontal, inferior parietal, and anterior cingulate regions.
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